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High risk factors for pulmonary fungous infection in intensive care units of neurosurgery
ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing
《医学前沿(英文)》 2007年 第1卷 第3期 页码 299-303 doi: 10.1007/s11684-007-0057-8
关键词: seventeen incidence glucocorticoid broad-spectrum antibiotic Candidiasis
Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants
Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz
《环境科学与工程前沿(英文)》 2020年 第14卷 第5期 doi: 10.1007/s11783-020-1268-3
关键词: Zero-Valent Iron (ZVI) Oxidants Heavy Metals (HMs) Metalloids Nitrate Phosphate
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用 Article
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
《工程(英文)》 2024年 第32卷 第1期 页码 42-57 doi: 10.1016/j.eng.2023.08.001
A universal vaccine is in high demand to address the uncertainties of antigenic drift and the reduced effectiveness of current influenza vaccines. In this study, a strategy called computationally optimized broadly reactive antigen (COBRA) was used to generate a consensus sequence of the hemagglutinin globular head portion (HA1) of influenza virus samples collected from 1918 to 2021 to trace evolutionary changes and incorporate them into the designed constructs. Constructs carrying different HA1 regions were delivered into eukaryotic cells by Salmonella-mediated bactofection using a Semliki Forest virus RdRp-dependent eukaryotic expression system, pJHL204. Recombinant protein expression was confirmed by Western blot and immunofluorescence assays. Mice immunized with the designed constructs produced a humoral response, with a significant increase in immunoglobulin G (IgG) levels, and a cell-mediated immune response, including a 1.5-fold increase in CD4+ and CD8+ T cells. Specifically, constructs #1 and #5 increased the production of interferon-γ (IFN-γ) producing CD4+ and CD8+ T cells, skewing the response toward the T helper type 1 cell (Th1) pathway. Additionally, interleukin-4 (IL-4)-producing T cells were upregulated 4-fold. Protective efficacy was demonstrated, with up to 4-fold higher production of neutralizing antibodies and a hemagglutination inhibition titer > 40 against the selected viral strains. The designed constructs conferred a broadly protective immune response, resulting in a notable reduction in viral titer and minimal inflammation in the lungs of mice challenged with the influenza A/PR8/34, A/Brisbane/59/2007, A/California/07/2009, KBPV VR-92, and NCCP 43021 strains. This discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1 is a highly effective in vivo antigen presentation strategy. This approach can effectively combat seasonal H1N1 influenza strains and potential pandemic outbreaks.
关键词: COBRA Influenza A Salmonella Vaccine Broad spectral protection
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1120-9
Reviewed the change of ARGs and ARB in full-scale urban drinking water systems. Conventional processes are more promising than BAC process in ARGs removal. Mechanisms of ARGs enrichment and spread in BAC filter and DWDSs are discussed. Raise the need of future research on ARGs and ARB change in building plumbing systems.
关键词: Antibiotic resistant bacteria Antibiotic resistance genes Water source Drinking water treatment plant Drinking water distribution system Urban drinking water system
Mirror system based therapy for autism spectrum disorders
CHEN Wei, ZHANG Jing, DING Jun
《医学前沿(英文)》 2008年 第2卷 第4期 页码 344-347 doi: 10.1007/s11684-008-0065-3
关键词: emotional cognition observation activation spectrum empirical research
《环境科学与工程前沿(英文)》 2022年 第16卷 第3期 doi: 10.1007/s11783-021-1469-4
• Distribution of ARGs in decentralized sewage facilities were investigated.
关键词: Decentralized sewage treatment facilities Antibiotic resistance genes Virus Metagenomics Network analysis
Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions
Xin Yu, Virender K. Sharma, Hui Li
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1137-0
The antibiotic resistome: gene flow in environments, animals and human beings
null
《医学前沿(英文)》 2017年 第11卷 第2期 页码 161-168 doi: 10.1007/s11684-017-0531-x
The antibiotic resistance is natural in bacteria and predates the human use of antibiotics. Numerous antibiotic resistance genes (ARGs) have been discovered to confer resistance to a wide range of antibiotics. The ARGs in natural environments are highly integrated and tightly regulated in specific bacterial metabolic networks. However, the antibiotic selection pressure conferred by the use of antibiotics in both human medicine and agriculture practice leads to a significant increase of antibiotic resistance and a steady accumulation of ARGs in bacteria. In this review, we summarized, with an emphasis on an ecological point of view, the important research progress regarding the collective ARGs (antibiotic resistome) in bacterial communities of natural environments, human and animals, i.e., in the one health settings. We propose that the resistance gene flow in nature is “from the natural environments” and “to the natural environments”; human and animals, as intermediate recipients and disseminators, contribute greatly to such a resistance gene “circulation.”
Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review
Sanli TANG, Jie SUN, Hui HONG, Qibin LIU
《能源前沿(英文)》 2017年 第11卷 第4期 页码 437-451 doi: 10.1007/s11708-017-0509-z
关键词: photo-thermal catalysis spectrum-selectivity solar fuel full-spectrum
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1124-5
Extracellular DNA structure damaged by chlorination was characterized. Integrity of extracellular ARG genetic information after chlorination was determined. Typical chlorine doses will likely effectively diminish extracellular DNA and ARGs. Plasmid DNA/ARGs were less readily broken down than genomic DNA. The Bioanalyzer methodology effectively documented damage incurred to DNA.
关键词: Antibiotic resistance Antibiotic resistance genes (ARGs) Extracellular DNA/ARGs Chlorination
Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,
《工程(英文)》 doi: 10.1016/j.eng.2023.04.015
关键词: Knowledge sharing Internet of Vehicles Federated learning Broad learning Reconfigurable intelligent surfaces Resource allocation
Analysis of antibiotic resistance of
Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan
《环境科学与工程前沿(英文)》 2019年 第13卷 第3期 doi: 10.1007/s11783-019-1123-6
The concentrations of four types of antibiotics in the Yitong River were detected. The concentration of total coliforms in summer was higher than that in spring. There was a seasonal difference in antibiotic resistance of E. coli. The E. coli in the Yitong River was found to have multiple antibiotic resistance.
关键词: Yitong River Coliform bacteria Antibiotic resistance Escherichia coli
MA Xiaoyan, CHEN Beibei, LI Qingsong, ZHANG Qiaoli, GU Guofen
《环境科学与工程前沿(英文)》 2007年 第1卷 第3期 页码 286-291 doi: 10.1007/s11783-007-0048-7
Antibiotic resistome of : molecular determinants for the emergence of drug resistance
《医学前沿(英文)》 2021年 第15卷 第5期 页码 693-703 doi: 10.1007/s11684-020-0777-6
关键词: S. typhi antibiotic resistance mechanism resistome identification methods
Qingkun Ji, Caihong Zhang, Dan Li
《环境科学与工程前沿(英文)》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1287-0
关键词: Nanofullerene Sub-minimum inhibitory concentrations Antibiotic resistance genes Conjugation Molecular biological techniques
标题 作者 时间 类型 操作
High risk factors for pulmonary fungous infection in intensive care units of neurosurgery
ZHU Wenyu, TAN Liping, CHEN Xiangfeng, HUANG Qiang, LAN Qing
期刊论文
Rapid and long-effective removal of broad-spectrum pollutants from aqueous system by ZVI/oxidants
Sana Ullah, Xuejun Guo, Xiaoyan Luo, Xiangyuan Zhang, Siwen Leng, Na Ma, Palwasha Faiz
期刊论文
从H1N1血凝素序列提取的沙门氏菌传递的COBRA-HA1抗原对甲型流感亚型产生广谱保护作用
Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee
期刊论文
Presence, dissemination and removal of antibiotic resistant bacteria and antibiotic resistance genes
Qiaowen Tan, Weiying Li, Junpeng Zhang, Wei Zhou, Jiping Chen, Yue Li, Jie Ma
期刊论文
Distribution of antibiotic resistance genes and their association with bacteria and viruses in decentralized
期刊论文
Environmental Antibiotics and Antibiotic Resistance: From Problems to Solutions
Xin Yu, Virender K. Sharma, Hui Li
期刊论文
Solar fuel from photo-thermal catalytic reactions with spectrum-selectivity: a review
Sanli TANG, Jie SUN, Hui HONG, Qibin LIU
期刊论文
Degradation of extracellular genomic, plasmid DNA and specific antibiotic resistance genes by chlorination
Menglu Zhang, Sheng Chen, Xin Yu, Peter Vikesland, Amy Pruden
期刊论文
Low-Cost Federated Broad Learning for Privacy-Preserved Knowledge Sharing in the RIS-Aided Internet of
Xiaoming Yuan,Jiahui Chen,Ning Zhang,Qiang Ye,Changle Li,Chunsheng Zhu,Xuemin Sherman Shen,
期刊论文
Analysis of antibiotic resistance of
Yangyang Yu, Xiaolin Zhu, Guanlan Wu, Chengzhi Wang, Xing Yuan
期刊论文
Detection of geosmin and 2-methylisoborneol by liquid-liquid extraction-gas chromatograph mass spectrum(LLE-GCMS) and solid phase extraction-gas chromatograph mass spectrum (SPE-GCMS)
MA Xiaoyan, CHEN Beibei, LI Qingsong, ZHANG Qiaoli, GU Guofen
期刊论文